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Key drivers in improving the performance of pharmaceutical companies
SPILLOproject provides a spectrum of specific services aimed at optimizing various phases of the drug discovery and development process.
By means of SPILLO-PBSS we can analyse the whole structural proteome of Homo sapiens and other organisms (e.g., Mus musculus, Rattus norvegicus) to highlight the potential target and off-target proteins of any small-molecule. In fact, in addition to the experimentally solved protein structures available from the RCSB Protein Data Bank (corresponding to approximately 40% of the human proteome), since July 2021 we also have the possibility to analyse the artificial intelligence (AI) predicted AlphaFold Protein Structure Database (corresponding to about 100% of the human proteome).
|RCSB Protein Data Bank
Solved by X-ray diffraction, solution NMR, cryo-EM
|AlphaFold Protein Structure Database
Predicted by AI (Released in: July 2021)
55,280+Structural coverage of the human proteome: ~ 40%
23,390+Structural coverage of the human proteome: ~100%
|Total:||66,550+ (April 2022)||66,260+ (July 2021)|
Structural details concerning the location of the potential binding sites on the protein structures and the relative 3D-orientation of the molecule are also provided by the analysis.