Key drivers in improving the performance of pharmaceutical companies

SPILLOproject provides a spectrum of specific services aimed at optimizing various phases of the drug discovery and development process. 

By means of SPILLO-PBSS we can analyse the whole structural proteome of Homo sapiens and other organisms (e.g., Mus musculus, Rattus norvegicus) to highlight the potential target and off-target proteins of any small-molecule. In fact, in addition to the experimentally solved protein structures available from the RCSB Protein Data Bank (corresponding to approximately 40% of the human proteome), since July 2021 we also have the possibility to analyse the artificial intelligence (AI) predicted AlphaFold Protein Structure Database (corresponding to about 100% of the human proteome).

Structural details concerning the location of the potential binding sites on the protein structures and the relative 3D-orientation of the molecule are also provided by the analysis.