Experimental validations / Publications

SPILLO-PBSS results have been experimentally confirmed by academic research centres and published in peer-reviewed scientific journals


Spillo background

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Fraisinib: a calixpyrrole derivative reducing A549 cells-derived NSCLC tumor in-vivo, acts as ligand of the Glycine-tRNA Synthase, a new molecular target in oncology

FRONTIERS IN PHARMACOLOGY (2023) - Ben Toumia I, Bachetti T, Chekig-Ghedira L, Profumo A, Ponassi M, Di Domizio A, Izzotti A, Sciacca S, et al.

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Identification of a novel off-target of paroxetine: possible role in sexual dysfunction induced by this SSRI antidepressant drug.

JOURNAL OF MOLECULAR STRUCTURE (2022) - Giatti S, Di Domizio A, Diviccaro S, Cioffi L, Marmorini I, Falvo E, Caruso D, Contini A, and Melcangi RC

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MV1035 Overcomes Temozolomide Resistance in Patient-Derived Glioblastoma Stem Cell Lines

BIOLOGY (2022) - Malacrida A, Di Domizio A, Bentivegna A, Cislaghi G, Messuti E, Tabano SM, Giussani C, Zuliani V, Rivara M, and Nicolini G

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Tubulin binding potentially clears up Bortezomib and Carfilzomib differential neurotoxic effect

SCIENTIFIC REPORTS (2021) - Malacrida A, Semperboni S, Di Domizio A, Palmioli A, Broggi L, Airoldi C, Meregalli C, Cavaletti G, and Nicolini G

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3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line

BIOORGANIC & MEDICINAL CHEMISTRY (2020) - Malacrida A, Rivara M, Di Domizio A, Cislaghi G, Miloso M, Zuliani V, and Nicolini G

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Three-Dimensional Proteome-Wide Scale Screening for the 5-Alpha Reductase Inhibitor Finasteride: Identification of a Novel Off-Target

JOURNAL OF MEDICINAL CHEMISTRY (2021) - Giatti S, Di Domizio A, Diviccaro S, Falvo E, Caruso D, Contini A, and Melcangi RC

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